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February 2023 Publications

Occurrence and tissue-specific partitioning of alternative brominated flame retardants in northwest Atlantic harbor seal pups (Phoca vitulina vitulina) 

High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways 

Uptake, translocation, bioaccumulation, and bioavailability of organophosphate esters in rice paddy and maize fields 

2,2',4,4',5,5'-Hexabromophenyl ether (BDE-153) causes abnormal insulin secretion and disorders of glucose and lipid metabolism in mice.

Growth inhibition of offspring larvae caused by the maternal transfer effects of tetrabromobisphenol A in zebrafish.

BDE-209 disrupted the blood-testis barrier integrity by inhibiting estrogen receptor α signaling pathway in Sprague-Dawley rats.

Polybrominated diphenyl ethers and bromophenols in paired serum, hair, and urine samples of e-waste dismantlers: Insights into hair as an indicator of endogenous exposure.

Chemical contaminant exposures assessed using silicone wristbands among occupants in office buildings in the USA, UK, China, and India (from 2021 but very important so distributed)

Relationships of prenatal organophosphate ester exposure with pregnancy and birth outcomes: A systematic scoping review of epidemiological studies 

Exposure to novel brominated and organophosphate flame retardants and associations with type 2 diabetes in East China: A case-control study.

Associated long-term effects of decabromodiphenyl ethane on the gut microbial profiles and metabolic homeostasis in Sprague-Dawley rat offspring.

Downregulation of miRNA-155-5p contributes to the adipogenic activity of 2-ethylhexyl diphenyl phosphate in 3T3-L1 preadipocytes.

Multi- and Transgenerational Developmental Impairments Are Induced by Decabromodiphenyl Ethane (DBDPE) in Zebrafish Larvae.

First insight into accumulation of characteristics and tissue distribution of PCBs, PBDEs, and other BFRs in the living Indonesian coelacanth (Latimeria menadoensis).

Bioaccumulation Behavior and Human Health Risk of Polybrominated Diphenyl Ethers in a Freshwater Food Web of Typical Shallow Lake, Yangtze River Delta.

Distribution, sources and dispersion of polybrominated diphenyl ethers in the water column of the Strait of Georgia, British Columbia, Canada.

Target and Nontarget Screening of Organic Chemicals and Metals in Recycled Plastic Materials

January 2023 Publications

Urinary concentrations of organophosphate esters in relation to semen quality: A cross-sectional study.


Independent and combined effects of exposure to organophosphate esters on thyroid hormones in children and adolescents.


Maternal Organophosphate Flame Retardant Exposure Alters the Developing Mesencephalic Dopamine System in Fetal Rat.


Gestation and lactation triphenyl phosphate exposure disturbs offspring gut microbiota in a sex-dependent pathway.


Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats.


The brominated flame retardant, 1,2,5,6-tetrabromocyclooctane (TBCO), causes multigenerational effects on reproductive capacity of Japanese medaka (Oryzias latipes).


The effects of hexabromocyclododecane on the transcriptome and hepatic enzyme activity in three human HepaRG-based models.


Triphenyl phosphate induced reproductive toxicity through the JNK signaling pathway in Caenorhabditis elegans.


In vitro neurotoxic potential of emerging flame retardants on neuroblastoma cells in an acute exposure scenario.


Tetrabromobisphenol A and hexabromocyclododecane, brominated flame retardants, trigger endoplasmic reticulum stress and activate necroptosis signaling in PC12 cells.


Distribution and pollution characteristics of organophosphate esters: reflected by tree rings of arbor species.


Long-Term Monitoring of Polybrominated Diphenyl Ethers (PBDEs) in Indo-Pacific Humpback Dolphins (Sousa chinensis) from the Pearl River Estuary Reveals High Risks for Calves due to Maternal Exposure.


Legacy and novel brominated flame retardants in agricultural soils of eastern China (2011-2021): Concentration level, temporal trend, and health risk assessment.


Eucalyptol antagonized the apoptosis and immune dysfunction of grass carp hepatocytes induced by tetrabromobisphenol A by regulating ROS/ASK1/JNK pathway.


Continuous and discontinuous multi-generational disturbances of tetrabromobisphenol A on longevity in Caenorhabditis elegans.


Differences in mirex [dechlorane] and dechlorane plus [syn- and anti-] concentrations observed in Canadian human milk.


Disentangling Source Profiles and Time Trends of Halogenated Flame Retardants in the Great Lakes.


Atmospheric deposition contributed mostly to organophosphorus flame retardant entering into the Bohai Sea, China.


Current status of indoor dust PBDE pollution and its physical burden and health effects on children.


Distribution and exposure risk assessment of chlorinated paraffins and novel brominated flame retardants in toys.


Is it really safe to replace decabromodiphenyl ether (BDE209) with decabromodiphenyl ethane (DBDPE)?: A perspective from hepatotoxicity.


Replacement Flame-Retardant 2-Ethylhexyldiphenyl Phosphate (EHDPP) Disrupts Hepatic Lipidome: Evidence from Human 3D Hepatospheroid Cell Culture.


Triphenyl phosphate proved more potent than its metabolite diphenyl phosphate in inducing hepatic insulin resistance through endoplasmic reticulum stress.


Neurodevelopmental toxicity of organophosphate flame retardant triphenyl phosphate (TPhP) on zebrafish (Danio rerio) at different life stages.


Biotransformation of Organophosphate Esters by Rice and Rhizosphere Microbiome: Multiple Metabolic Pathways, Mechanism, and Toxicity Assessment.


Triphenyl phosphate-induced pericardial edema in zebrafish embryos is dependent on the ionic strength of exposure media.


Gene expression profiling after exposure to a chemical carcinogen, Pentabrominated Diphenyl Ether, at different life stages.


Impact of the flame retardant 2,2'4,4'-tetrabromodiphenyl ether (PBDE-47) in THP-1 macrophage-like cell function via small extracellular vesicles.


Novel Brominated Flame Retardants in Dust from E-Waste-Dismantling Workplace in Central China: Contamination Status and Human Exposure Assessment.

December 2023 Publications


Tetrabromobisphenol Exposure Impairs Bovine Oocyte Maturation by Inducing Mitochondrial Dysfunction.


A transcriptomic-based analysis predicts the neuroendocrine disrupting effect on adult male and female zebrafish (Danio rerio) following long-term exposure to Tetrabromobisphenol A bis(2-hydroxyethyl) ether.


Toxicokinetics and edible tissues-specific bioaccumulation of decabrominated diphenyl ethers (BDE-209) after exposure to the broilers.


Organophosphorus Flame Retardant TCPP Induces Cellular Senescence in Normal Human Skin Keratinocytes: Implication for Skin Aging.


Elevated concentrations of halogenated flame retardants in waste childcare articles from Ireland.


Exposure to flame retardants in European children - Results from the HBM4EU aligned studies.


Polybrominated diphenyl ethers and polycyclic aromatic hydrocarbons in dust from different indoor environments in Zagreb, Croatia: Levels and human exposure assessment.


Sediment contamination with polybrominated diphenyl ethers and alternative brominated flame retardants: case study in urban lakes of Hanoi, Vietnam.


The role of polybrominated diphenyl ethers in the induction of cancer: a systematic review of insight into their mechanisms.


Gestational organophosphate ester exposure and preschool attention-deficit/hyperactivity disorder in the Norwegian Mother, Father, and Child cohort study.


Exposure to Novel Brominated Flame Retardants and Organophosphate Esters and Associations with Thyroid Cancer Risk: A Case-Control Study in Eastern China.


The potential mechanisms of TBBPA bis(2-hydroxyethyl) ether induced developmental neurotoxicity in juvenile zebrafish (Danio rerio).


Discovery of 18 Organophosphate Esters and 3 Organophosphite Antioxidants in Food Contact Materials Using Suspect and Nontarget Screening: Implications for Human Exposure.


Halogenated flame retardant exposure pathways in urban-adapted gulls: Are atmospheric routes underestimated?


Occurrence, spatial distribution, and risk assessment of brominated flame retardants in farmland soils of typical provinces in China.


Gestational exposure to organophosphate esters and adiposity measures of children up to 6 years: Effect modification by breastfeeding.


Time- and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis.


Tetrabromobisphenol A and Diclazuril Evoke Tissue-Specific Changes of Thyroid Hormone Signaling in Male Thyroid Hormone Action Indicator Mice.


Chlorinated Organophosphate Flame Retardants Impair the Lung Function via the IL-6/JAK/STAT Signaling Pathway.


Histopathological and transcriptomic analyses reveal the reproductive endocrine-disrupting effects of decabromodiphenyl ethane (DBDPE) in mussel Mytilus galloprovincialis.


Tris(1,3-dichloro-2-propyl) phosphate is a metabolism-disrupting chemical in male mice.


BDE-99 (2,2',4,4',5 - pentain polybrominated diphenyl ether) induces toxic effects in Oreochromis niloticus after sub-chronic and oral exposure.


Occurrence of organophosphorus esters in outdoor air fine particulate matter and comprehensive assessment of human exposure: A global systematic review.


A Review of Hydroxylated and Methoxylated Brominated Diphenyl Ethers in Marine Environments.


Postnatal exposure to low-dose tetrabromobisphenol A increases the susceptibility of mammal testes to chemical-induced spermatogenic stress in adulthood.


Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics.


Genotoxic and Toxic Effects of The Flame Retardant Tris(Chloropropyl) Phosphate (TCPP) in Human Lymphocytes, Microalgae and Bacteria.


Seasonal and source characteristics of organophosphorus flame retardants in air and house dust in Taiwan residential microenvironments: Implications for young children's exposure and risk assessment using a probabilistic approach.


Exposure and Risk Assessment of Korean Firefighters to PBDEs and PAHs via Fire Vehicle Dust and Personal Protective Equipment.


Temporal trends in concentrations of brominated flame retardants in UK foodstuffs suggest active impacts of global phase-out of PBDEs and HBCDD.


Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers.


BDE-47, -99, -209 and Their Ternary Mixture Disrupt Glucose and Lipid Metabolism of Hepg2 Cells at Dietary Relevant Concentrations: Mechanistic Insight through Integrated Transcriptomics and Proteomics Analysis.


Effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on reproductive and endocrine function in female zebrafish (Danio rerio).

November 2022 Publications

 A review on organophosphate esters: Physiochemical properties, applications, and toxicities as well as occurrence and human exposure in dust environment.


Associations of gestational exposure to organophosphate esters with gestational age and neonatal anthropometric measures: The HOME study.


Environmental exposure to organophosphate esters and suspected non-alcoholic fatty liver disease among US adults: A mixture analysis.


Associations between exposure to brominated flame retardants and metabolic syndrome and its components in U.S. adults.


Aryl-, halogenated- and alkyl- organophosphate esters induced oxidative stress, endoplasmic reticulum stress and NLRP3 inflammasome activation in HepG2 cells.


In vivo and in vitro study on hepatotoxicity of Tris-(2, 3-dibromopropyl) isocyanurate exposure via mitochondrial and death receptor pathway. 

Decabromodiphenyl ethane induces male reproductive toxicity by glycolipid metabolism imbalance and meiotic failure. 


Exploratory analysis of the association between organophosphate ester mixtures with high blood pressure of children and adolescents aged 8-17 years: cross-sectional findings from the National Health and Nutrition Examination Survey.


Adipose tissue levels of polybrominated diphenyl ethers in relation to prognostic biomarkers and progression-free survival time of breast cancer patients in eastern area of southern China: A hospital-based study.


Prenatal Exposure of Organophosphate Esters and Its Trimester-Specific and Gender-Specific Effects on Fetal Growth.


Adverse effects of thyroid-hormone-disrupting chemicals 6-propyl-2-thiouracil and tetrabromobisphenol A on Japanese medaka (Oryzias latipes).


Triphenyl phosphate induces clastogenic effects potently in mammalian cells, human CYP1A2 and 2E1 being major activating enzymes.


PBDEs disrupt homeostasis maintenance and regeneration of planarians due to DNA damage, proliferation and apoptosis anomaly.


Developmental exposure to the flame retardant, triphenyl phosphate, causes long-lasting neurobehavioral and neurochemical dysfunction.


Ubiquitin proteasomal system is a potential target of the toxic effects of organophosphorus flame retardant triphenyl phosphate.


Tetrabromobisphenol A effects on differentiating mouse embryonic stem cells reveals unexpected impact on immune system.


Bioavailability of non-aromatic brominated flame retardants in rats from dust and oil vehicles.


Parental whole life-cycle exposure to tris (2-chloroethyl) phosphate (TCEP) disrupts embryonic development and thyroid system in zebrafish offspring.


Handwipes as indicators to assess organophosphate flame retardants exposure and thyroid hormone effects in e-waste dismantlers.


Partitioning behavior-oriented health risk assessment on internal organophosphorus flame retardants exposure.


Hazardous organic pollutants in indoor dust from elementary schools and kindergartens in Greece: Implications for children's health. 


Fireproofing of domestic upholstered furniture: Migration of flame retardants and potential risks (from 2019)

Legacy and novel brominated flame retardants in animal-derived foods from China Total Diet Study (CTDS): Temporal trends, evidence of substitution, and dietary exposure assessment.


Safety of recycled plastics and textiles: Review on the detection, identification and safety assessment of contaminants 

Fetal exposure to organic contaminants revealed by infant hair: A preliminary study in south China 

Real time degradation studies on polyurethane household sponges in Danish weather and marine environments 

Uptake Kinetics, Accumulation, and Long-Distance Transport of Organophosphate Esters in Plants: Impacts of Chemical and Plant Properties (from 2019)


Mixed bromine/chlorine transformation products of tetrabromobisphenol A formed in the combustion of printed circuit boards: Emission characteristics and transformation pathways.


Presence of novel and legacy flame retardants and other pollutants in an e-waste site in China and associated risks.


Occurrence and ecological risk assessment of 2,2',4,4'-tetrabromodiphenyl ether and decabromodiphenyl ether in surface waters across China.


Chlorinated organophosphate esters in Irish waste foams and fabrics: Concentrations, preliminary assessment of temporal trends and evaluation of the impact of a concentration limit value 

Leaching of TCIPP from furniture foam is rapid and substantial (from 2018)

October 2022 Publications 

Exposure to flame retardants in European children - Results from the HBM4EU aligned studies 

The interaction mechanisms of co-existing polybrominated diphenyl ethers and engineered nanoparticles in environmental waters: A critical review.


Prenatal exposure to organophosphate esters is associated with decreased anogenital distance in offspring.


Parental and transgenerational impairments of thyroid endocrine system in zebrafish by 2,4,6-tribromophenol.


Photolytic degradation of novel polymeric and monomeric brominated flame retardants: Investigation of endocrine disruption, physiological and ecotoxicological effects.


Metabolic perturbations in human hepatocytes induced by bis (2-ethylhexyl)-2,3,4,5-tetrabromophthalate exposure: Insights from high-coverage quantitative metabolomics.


Transcriptomic sequencing reveals the potential molecular mechanism by which Tetrabromobisphenol A bis (2-hydroxyethyl ether) exposure exerts developmental neurotoxicity in developing zebrafish (Danio rerio).


Gestational exposure to organophosphate esters and infant anthropometric measures in the first 4 weeks after birth.


Early exposure to flame retardants is prospectively associated with anxiety symptoms in adolescents: A prospective birth cohort study.


Tetramethyl bisphenol A stimulates proliferation but inhibits fetal Leydig cell function in male rats by targeting estrogen receptor α after in utero exposure.

Exposure to melamine cyanuric acid in adult mice caused motor activity and skeletal muscle energy metabolism disorder. 


Metabolite alterations in zebrafish embryos exposed to hydroxylated polybrominated diphenyl ethers.


Distribution of flame retardants among indoor dust, airborne particles and vapour phase from Beijing: spatial-temporal variation and human exposure characteristics.


A global survey of organophosphate esters and their metabolites in milk: Occurrence and dietary intake via milk consumption.


Pregnant Women's perceptions of exposure to brominated flame retardants (from 2016)


Knowledge and attitudes regarding exposure to brominated flame retardants: a survey of Croatian health care providers (from 2019)


Synergistic action of organophosphates and COVID-19 on inflammation, oxidative stress, and renin-angiotensin system can amplify the risk of cardiovascular maladies.


The associations between renal disease severity and exposure to organophosphate flame retardants in patients with chronic kidney disease.


In vivo and in vitro study on hepatotoxicity of Tris-(2, 3-dibromopropyl) isocyanurate exposure via mitochondrial and death receptor pathway.


Triphenyl phosphate activates estrogen receptor α/NF-κB/cyclin D1 signaling to stimulate cell cycle progression in human Ishikawa endometrial cancer cells.


Occurrence of emerging brominated flame retardants and organophosphate esters in marine wildlife from the Norwegian Arctic.


Occurrence and ecological risks of brominated flame retardants and dechlorane plus in sediments from the Pearl River Estuary and Daya Bay, South China.


Concentration, Distribution and Biomagnification of Novel Brominated Flame Retardant in Grassland Food Chain and Sheep from Inner Mongolia, China.


A Pilot Study on the Concentration, Distribution and Bioaccumulation of Polybrominated Diphenyl Ethers (PBDEs) in Tissues and Organs of Grassland Sheep.


Thyroid hormone activities of neutral and anionic hydroxylated polybrominated diphenyl ethers to thyroid receptor β: A molecular dynamics study.


Developmental toxicity assessments for TBBPA and its commonly used analogs with a human embryonic stem cell liver differentiation model.


Tetrabromobisphenol a exacerbates the overall radioactive hazard to zebrafish (Danio rerio).


PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.


Developmental exposure to indoor flame retardants and hypothalamic molecular signatures: Sex-dependent reprogramming of lipid homeostasis.


Maternal transfer and apical and physiological effects of dietary hexabromocyclododecane exposure in parental fathead minnows (Pimephales promelas).


The effect of 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) on locomotor behaviour and muscle physiology of the sea cucumber Apostichopus japonicus.


Polybrominated diphenyl ethers interact with the key protein involved in carbohydrate metabolism in rice.


Bioaccumulation and Biomagnification of Hexabromocyclododecane in Marine Biota from China: A Review.

September 2022 Publications 

Decabromodiphenyl ethane induced hyperactivity in developing zebrafish at environmentally relevant concentrations.


Unintentional formation of mixed chloro-bromo diphenyl ethers (PBCDEs), dibenzo-p-dioxins and dibenzofurans (PBCDD/Fs) from pyrolysis of polybrominated diphenyl ethers (PBDEs).


Dietary intake assessment of known and unknown organophosphate esters (OPEs) in foodstuffs via high-resolution mass spectrometry.


Novel Organophosphate Esters in Airborne Particulate Matters: Occurrences, Precursors, and Selected Transformation Products 


Non-target screening and risk assessment of organophosphate esters (OPEs) in drinking water resource water, surface water, groundwater, and seawater 


Exposure assessment of aryl-organophosphate esters based on specific urinary biomarkers and their associations with reproductive hormone homeostasis disruption in women of childbearing age.


Comprehensive analysis of triphenyl phosphate: An environmental explanation of colorectal cancer progression.


Organophosphorus flame retardant TDCPP induces neurotoxicity via mitophagy-related ferroptosis in vivo and in vitro.


Exposure to tris(1,3-dichloro-2-propyl) phosphate for two generations aggravates the adverse effects on survival and growth of zebrafish at environmentally relevant concentrations.


Sex-dependent effect of triphenyl phosphate on hepatic energy metabolism at the intersection of diet pattern in pubertal mice.


Triphenyl phosphate disturbs placental tryptophan metabolism and induces neurobehavior abnormal in male offspring.


Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters.


Biphasic effects of typical chlorinated organophosphorus flame retardants on Microcystis aeruginosa.


Potential Health Risk to Brazilian Infants by Polybrominated Diphenyl Ethers Exposure via Breast Milk Intake.


Physiologically based pharmacokinetic (PBPK) modeling of BDE-209 following oral exposure in Chinese population.


Biotransformation of Dec-604 and potential effect on thyroid deiodinase activity in highly flame retardant-exposed gulls.


Novel brominated flame retardants - A review of their occurrence in indoor air, dust, consumer goods and food (from 2020)


Global responses to tris(1-chloro-2-propyl)phosphate (TCPP) in rockfish Sebastes schlegeli using integrated proteomic and metabolomic approach (from 2020)


Childhood urinary organophosphate esters and cognitive abilities in a longitudinal cohort study.


Association of organophosphate ester exposure with cardiovascular disease among US adults: Cross-sectional findings from the 2011-2018 National Health and Nutrition Examination Survey.


Organophosphate ester exposure among Chinese waste incinerator workers: Urinary levels, risk assessment and associations with oxidative stress.


Correlates of Positive Thyroid Peroxidase Antibodies Among Firefighters: A Cross-Sectional-Study.


Chlorinated organophosphorus flame retardants-induced mitochondrial abnormalities and the correlation with progesterone production in mLTC-1 cells.


Silicone wristband- and handwipe-based assessment of exposure to flame retardants for informal electronic-waste and end-of-life-vehicle recycling workers and their children in Vietnam.


Organophosphate esters in UK diet; exposure and risk assessment.


Organophosphate tri-esters and di-esters in drinking water and surface water from the Pearl River Delta, South China: Implications for human exposure.


Spatiotemporal transitions of organophosphate esters (OPEs) and brominated flame retardants (BFRs) in sediments from the Pearl River Delta, China.


Legacy and novel brominated flame retardants in air of Ny-Ålesund, Arctic from 2011 to 2019.


Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease  (from 2021)


Associations between organophosphate esters concentrations and markers of liver function in US adolescents aged 12-19 years: A mixture analysis.

Organophosphate esters cause thyroid dysfunction via multiple signaling pathways in zebrafish brain.

Probiotics protect against hepatic steatosis in tris (2-chloroethyl) phosphate-induced metabolism disorder of mice via FXR signaling.

BDE-47 disturbs the immune response of lymphocytes to LPS by downregulating NF-κB pathway.

Hepatic Gene Expression Profiling of American Kestrels (Falco sparverius) Exposed In Ovo to Three Alternative Brominated Flame Retardants.

Determination of Apoptotic Mechanism of Action of Tetrabromobisphenol A and Tetrabromobisphenol S in Human Peripheral Blood Mononuclear Cells: A Comparative Study.

Vascular Response of Tetrabromobisphenol a in Rat Aorta: Calcium Channels Inhibition and Potassium Channels Activation.

Integration of transcriptomic and proteomic reveals the toxicological molecular mechanisms of decabromodiphenyl ethane (DBDPE) on Pleurotus ostreatus.

Monitoring Human Exposure to Organophosphate Esters: Comparing Silicone Wristbands with Spot Urine Samples as Predictors of Internal Dose.

Occurrence, distribution, and ecological risk of organophosphorus flame retardants and their degradation products in water and upper sediment of two urban rivers in Shenzhen, China.

Extent and mechanisms of brominated flame retardant emissions from waste soft furnishings and fabrics: A critical review  (from 2014 – note the authors conclusion: We propose that waste soft furnishings be treated with the same concern as e-waste, given its potential as a reservoir and source of environmental contamination with BFRs.)

In Utero and Lactational Exposure to an Environmentally Relevant Mixture of Brominated Flame Retardants Induces a Premature Development of the Mammary Glands (from 2021)

August 2022 Publications 

Metabolism toxicity and susceptibility of decabromodiphenyl ether (BDE-209) exposure on BRL cells with insulin resistance.

Hormesis-Like Effects of Tetrabromobisphenol A on Anaerobic Digestion: Responses of Metabolic Activity and Microbial Community.

An overview of organophosphate esters and their metabolites in humans: Analytical methods, occurrence, and biomonitoring.

Association between organophosphorus flame retardants exposure and cognitive impairment among elderly population in southern China.

Bidirectional regulation of BDE-47 on 3T3-L1 cell differentiation based on a restricted cubic spline model.

Melatonin administration alleviates 2,2,4,4-tetra-brominated diphenyl ether (PBDE-47)-induced necroptosis and secretion of inflammatory factors via miR-140-5p/TLR4/NF-κB axis in fish kidney cells.

Polybrominated diphenyl ether quinone exposure leads to ROS-driven lysosomal damage, mitochondrial dysfunction and NLRP3 inflammasome activation.

Occurrence, emission sources, and risk assessment of polybrominated diphenyl ethers and current-use brominated flame retardants in settled dust from end-of-life vehicle processing, urban, and rural areas, northern Vietnam.

Pollution level, spatial distribution, and congener fractionation characteristics of low-brominated polybrominated diphenyl ethers (PBDEs) in sediments around Chaohu Lake, China.

Associations between polybrominated diphenyl ethers (PBDEs) levels in adipose tissues and blood lipids in women of Shantou, China.

Insights into the Atmospheric Persistence, Transformation, and Health Implications of Organophosphate Esters in Urban Ambient Air.

Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice.

The disruption on gut microbiome of Decabromodiphenyl ethane exposure in the simulator of the human intestinal microbial ecosystem (SHIME).

Percutaneous absorption and exposure risk assessment of organophosphate esters in children's toys.

Occurrence, spatial variation, seasonal difference, and ecological risk assessment of organophosphate esters in the Yangtze River, China: From upper to lower reaches.

Occurrence and removal of organophosphate esters in municipal wastewater treatment plants in Thessaloniki, Greece 

A systematic scoping review of epidemiological studies on the association between organophosphate flame retardants and neurotoxicity.

Decabromodiphenyl ethane induces locomotion neurotoxicity and potential Alzheimer's disease risks through intensifying amyloid-beta deposition by inhibiting transthyretin/transthyretin-like proteins.

Pre- and post-natal exposure of children to organophosphate flame retardants: A nationwide survey in France.

Organophosphate tri- and diesters in source water supply and drinking water treatment systems of a metropolitan city in China.

Novel brominated and organophosphate flame retardants in the atmosphere of Fildes Peninsula, West Antarctica: Continuous observations from 2011 to 2020.

Early life organophosphate ester exposures and bone health at age 12 years: The Health Outcomes and Measures of the Environment (HOME) study 

Low-dose exposure to PBDE disrupts genomic integrity and innate immunity in mammary tissue.

Profiling of multiple classes of flame retardants in house dust in China: Pattern analysis and human exposure assessment.

July 2022 Publications 

Carcinogenicity of occupational exposure as a firefighter (From IARC and includes flame retardants)

New Insights into Human Biotransformation of BDE-209: Unique Occurrence of Metabolites of Ortho-Substituted Hydroxylated Higher Brominated Diphenyl Ethers in the Serum of e-Waste Dismantlers.

Low concentration triphenyl phosphate fuels proliferation and migration of hepatocellular carcinoma cells.

Tris (2-chloroethyl) phosphate (TCEP) induces obesity and hepatic steatosis via FXR-mediated lipid accumulation in mice: Long-term exposure as a potential risk for metabolic diseases.

Distribution and source of and health risks associated with polybrominated diphenyl ethers in dust generated by public transportation.

Effects of Polybrominated Diphenyl Ethers on Hormonal and Reproductive Health in E-Waste-Exposed Population: A Systematic Review.

In utero exposure to Decabromodiphenyl ethane causes rapid growth in mice cubs by activating glycogenolysis and lipid synthesis.

Factors Influencing Dechlorane plus Distributions in Various Sheep Tissues.

Organophosphate Esters in Foodstuffs from Multiple Provinces in China: Possible Sources during Food Processing and Implications for Human Exposure.

Significant input of organophosphate esters through particle-mediated transport into the Pearl River Estuary, China.

Mixture of environmental pollutants in breast milk from a Spanish cohort of nursing mothers 

Exposure of men living in the greater Montreal area to organophosphate esters: Association with hormonal balance and semen quality.

Developmental exposure to the brominated flame retardant DE-71 reduces serum thyroid hormones in rats without hypothalamic-pituitary-thyroid axis activation or neurobehavioral changes in offspring.

Vitamin C supplementation rescued meiotic arrest of spermatocytes in Balb/c mice exposed to BDE-209.

Developmental exposure to the brominated flame retardant DE-71 reduces serum thyroid hormones in rats without hypothalamic-pituitary-thyroid axis activation or neurobehavioral changes in offspring.

Characterization of 2,2',4,4'-tetrabromodiphenyl ether (BDE47)-induced testicular toxicity via single-cell RNA-sequencing.

Hesperidin partly ameliorates the decabromodiphenyl ether-induced reproductive toxicity in pubertal mice.

Human exposure to polybrominated diphenyl ethers (PBDEs) through the diet: An update of the scientific literature.


June 2022 Publications

Sources, behaviors, transformations, and environmental risks of organophosphate esters in the coastal environment: A review 

Associations between prenatal exposure to polybrominated diphenyl ethers and physical growth in a seven year cohort study 

Individual and Combined Effects of Paternal Deprivation and Developmental Exposure to Firemaster 550 on Socio-Emotional Behavior in Prairie Voles 

Transcriptomic profiling and differential analysis revealed the neurodevelopmental toxicity and mechanisms of zebrafish (Danio rerio) larvae in response to tetrabromobisphenol A bis(2-hydroxyethyl) ether (TBBPA-DHEE) exposure 

Association of Flame-Retardant Clothing With Mycosis Fungoides: A Retrospective Analysis 

The respiratory cytotoxicity of typical organophosphorus flame retardants on five different respiratory tract cells: Which are the most sensitive one?

Triphenyl phosphate (TPP) promotes hepatocyte toxicity via induction of endoplasmic reticulum stress and inhibition of autophagy flux.

Exposure to tris(2-butoxyethyl) phosphate induces abnormal sperm morphology and testicular histopathology in male rats.

Penetration of Organophosphate Triesters and Diesters across the Blood-Cerebrospinal Fluid Barrier: Efficiencies, Impact Factors, and Mechanisms.

Riverine transport dynamics of PBDEs and OPFRs within a typical e-waste recycling zone: Implications for sink-source interconversion 

Development of a Flame Retardant and an Organohalogen Flame Retardant Chemical Inventory.

Hormetic dose responses induced by organic flame retardants in aquatic animals: Occurrence and quantification 

A single-cell survey unveils cellular heterogeneity and sensitive responses in mouse cortices induced by oral exposure to triphenyl phosphate.

Biomarker Responses, Gene Expression Alterations, and Histological Changes in Zebrafish (Danio rerio) After In Vivo Exposure to Polychlorinated Diphenyl Ethers.

Exposure to Polybrominated Diphenyl Ether Flame Retardants Causes Deoxyribonucleic Acid Damage in Human Thyroid Cells In Vitro.

Organophosphate flame retardant TDCPP: A risk factor for renal cancer?

Global PBDE contamination in cetaceans. A critical review.


Spatial distribution and risk assessment of 11 organophosphate flame retardants in soils from different regions of agricultural farmlands in mainland China.

May 2022 Publications


Metabolomics insights into the prenatal exposure effects of polybrominated diphenyl ethers on neonatal birth outcomes.

Screening of Organophosphate Flame Retardants with Placentation-Disrupting Effects in Human Trophoblast Organoid Model and Characterization of Adverse Pregnancy Outcomes in Mice.

Genotoxic Mechanism of Action of TBBPA, TBBPS and Selected Bromophenols in Human Peripheral Blood Mononuclear Cells.

Tetramethyl bisphenol a inhibits leydig cell function in late puberty by inducing ferroptosis.

Do flame retardant concentrations change in dust after older upholstered furniture is replaced? (from 2021)

TBBPA downregulates thyroid receptor and estrogen receptor mRNA levels in goldfish gonadal tissue 

The first detection of organophosphate esters (OPEs) of a high altitude fresh snowfall in the northeastern Tibetan Plateau 

Insights into the long-term fates and impacts of polybrominated diphenyl ethers in sediment samples in Taiwan: The national project for background monitoring of the environmental distribution of chemical substances (BMECs) 

Infants' diminished response to DTaP vaccine is associated with exposure to organophosphate esters 

Associations between organophosphate esters metabolites and sleep disorder and trouble sleeping in adults: a machine-learning approach 

Effects of Developmental Exposure to FireMaster® 550 (FM 550) on Microglia Density, Reactivity and Morphology in a Prosocial Animal Model 

Polybrominated diphenyl ethers in early pregnancy and preterm birth: Findings from the NICHD Fetal Growth Studies 

Trophic transfer of methylmercury and brominated flame retardants in adjacent riparian and aquatic food webs: 13 C indicates biotransport of contaminants through food webs 

Toxic effects of polystyrene nanoplastics and polybrominated diphenyl ethers to zebrafish (Danio rerio) 

Polybrominated diphenyl ethers (PBDEs) in Indian wastewater treatment plant: Occurrence, mass flow and removal 

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